Zubsolv treatment in Dayton, Ohio

What Zubsolv is

A sublingual tablet combining buprenorphine and naloxone, FDA-approved since 2013 as an alternative to buprenorphine/naloxone film.

Zubsolv contains the same two active medications as Suboxone — buprenorphine, a partial opioid agonist that eases withdrawal and cravings, and naloxone, an opioid antagonist included to discourage misuse. The difference is the delivery: rather than a film, Zubsolv is a small tablet that dissolves under the tongue, taken once daily after the initial induction period.

Zubsolv’s tablet formulation was engineered for higher bioavailability than standard buprenorphine/naloxone film — meaning it delivers a comparable clinical effect at roughly 30% lower buprenorphine dose. In practice, that’s paired with a faster dissolve time and a taste many patients find more tolerable than film alternatives, which can matter for someone taking a daily medication over months or longer.

Zubsolv vs. other buprenorphine options

Zubsolv, Suboxone, and buprenorphine alone all treat opioid use disorder using the same core medication. The differences come down to form and formulation: Suboxone is a film, Zubsolv is a tablet with faster dissolution and higher bioavailability, and options like Sublocade or Brixadi replace the daily dose with a monthly or weekly injection entirely. None is universally “better” — the right choice depends on what fits your routine, your response to the medication, and your physician’s guidance.